Aktuelles

Erste Nachricht

Erste nachricht. Erste nachricht. Erste nachricht. Erste nachricht. Erste nachricht.

Zweite Nachricht

Zweite Nachricht, Zweite Nachricht, Zweite Nachricht, Zweite Nachricht, Zweite Nachricht, Zweite Nachricht.
Universität Heidelberg > Einrichtungen  >

Surface Science & Analytics - Prof. (apl.) Dr. Michael Zharnikov

Design and applications of ultrathin membranes

Biocompatible nanomembranes based on PEGylation of cross-linked self-assembled monolayers

Chem. Mater. 24, 2965 (2012)

Nitro-functionalized aromatic SAMs on gold substrate were extensively cross-linked and selectively modified (nitro-to-amino transformation) by electron irradiation. The created amino groups served as the docking sites for the coupling of PEG moieties using a grafting-to method in such a way that the resulting PEGylated films become protein-repelling. Based on these PEGylated monolayers, we prepared ultrathin, mechanically stable, and protein-repelling membranes which can be used as a highly transparent support in TEM experiments. Whereas the ultimate thinness (< 5 nm)  and low atomic number character of this support material guarantee high imaging quality (low extent of electron scattering), its protein-repelling properties ensure the lack of protein denaturing, which may improve essentially the resolution and structural reliability of TEM and HRTEM experiments in their specific application to sensitive biological targets.
Responsible E-Mail Latest Revision: 23.05.2018
zum Seitenanfang/up